Browsing by Author "Karadağ A."

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    Preparation of a 99mTc-labeled graft polymer and its in vitro and in vivo evaluation
    (Springer Science and Business Media B.V., 2021) Avcıbaşı U.; Türkyarar T.; Karadağ A.; Bakan B.; Yavaşoğlu N.Ü.K.; Kuşat K.; Akgöl S.; Gülcemal D.; Tekin V.; Müftüler F.Z.B.; Topal G.; Parlak Y.; Gümüşer F.G.
    The aim of this study is the synthesis of a novel 99mTc-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with 99mTc. The radiochemical yield of approximately the 99mTc-labeled compound amounted to 97 ± 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate. © 2021, Akadémiai Kiadó, Budapest, Hungary.