Malkoc G.Dalgic A.Koc M.Kandogan T.Korkmaz S.Ceylan M.E.Inan S.Olgun L.2024-07-222024-07-22201400222151http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16817Objective: This study aimed to present the histopathological and audiological effects of mechanical trauma associated with the placement of a model electrode in the scala tympani in rats, and the effects of continuous topical corticosteroid application. Method: The study comprised three groups of rats. The round window membrane was perforated in all three groups and a model electrode was inserted in the round window. Group one received no further treatments. Groups two and three also had an intrathecal microcatheter compatible with a mini-osmotic pump inserted; in group two this was used to release normal saline and in group three the pump released 400 μg/ml dexamethasone. Results: Dexamethasone infusion given after implantation of the intracochlear model electrode was more effective for preventing hearing loss than the administration of just one dose of dexamethasone. Conclusion: The findings suggest that continuous dexamethasone infusion is beneficial for preventing the loss of hair cells and neurons associated with early and late periods of intracochlear electrode trauma. Copyright © JLO (1984) Limited 2014.EnglishAdministration, TopicalAdrenal Cortex HormonesAnimalsAudiometryCochleaCochlear ImplantsDexamethasoneFemaleRatsRound Window, Eardexamethasonesodium chloridecorticosteroiddexamethasoneanimal experimentanimal modelanimal tissuearticleaudiologycochlea fenestracontrolled studycorticosteroid therapydrug infusionear injuryeardrum perforationfemalehearing impairmenthistopathologyimplantationintracochlear prosthesismicrocatheternonhumanosmotic pumpprospective studyratscala tympanisignal noise ratiotopical treatmentadverse effectsanimalaudiometrycochleacochlea prosthesispathologypathophysiologysurgerytopical drug administrationArticle10.1017/S002221511400156X