Sousa-Pinto B.Louis G.Rodrigues J.Giuliano A.F.M.Baiardini I.Braido F.Czarlewski W.Bedbrook A.Haahtela T.Valiulis A.Brussino L.Cecchi L.Cruz A.A.Gemicioglu B.Fokkens W.J.Ivancevich J.C.Klimek L.Kraxner H.Kuna P.Kupczyk M.Kvedariene V.Larenas-Linnemann D.Louis R.Nadif R.Niedoszytko M.Okamoto Y.Ollert M.Papadopoulos N.G.Patella V.Pawankar R.Pham-Thi N.Pfaar O.Regateiro F.S.Roche N.Rouadi P.W.Samolinski B.Sastre J.Savouré M.Scichilone N.Sheikh A.Taborda-Barata L.Toppila-Salmi S.Yorgancioglu A.Zidarn M.Anto J.M.Zuberbier T.Canonica G.W.Ventura M.T.Fonseca J.A.Pétré B.Bousquet J.2024-07-222024-07-22202322132198http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11770Background: EQ-5D-5L (EuroQOL, 5 Domains, 5 Levels) is a widely used health-related quality-of-life instrument, comprising 5 domains. However, it is not known how each domain is impacted by rhinitis or asthma control. Objective: To assess the association between rhinitis or asthma control and the different EQ-5D-5L domains using data from the MASK-air mHealth app. Methods: In this cross-sectional study, we assessed data from all MASK-air users (2015-2021; 24 countries). For the levels of each EQ-5D-5L domain, we assessed rhinitis and asthma visual analog scales (VASs) and the combined symptom-medication score (CSMS). We built ordinal multivariable models assessing the adjusted association between VAS/CSMS values and the levels of each EQ-5D-5L domain. Finally, we compared EQ-5D-5L data from users with rhinitis and self-reported asthma with data from users with rhinitis alone. Results: We assessed 5354 days from 3092 users. We observed an association between worse control of rhinitis or asthma (higher VASs and CSMS) and worse EQ-5D-5L levels. In multivariable models, all VASs and the CSMS were associated with higher levels of pain/discomfort and daily activities. For anxiety/depression, the association was mostly observed for rhinitis-related tools (VAS nose, VAS global, and CSMS), although the presence of self-reported asthma was also associated with worse anxiety/depression. Worse mobility (“walking around”) was particularly associated with VAS asthma and with the presence of asthma. Conclusions: A worse rhinitis control and a worse asthma control are associated with higher EQ-5D-5L levels, particularly regarding pain/discomfort and activity impairment. Worse rhinitis control is associated with worse anxiety/depression, and poor asthma control with worse mobility. © 2023 American Academy of Allergy, Asthma & ImmunologyEnglishAll Open Access; Green Open AccessAsthmaCross-Sectional StudiesHealth StatusHumansPainQuality of LifeRhinitis, AllergicSurveys and Questionnairesadolescentadultagedallergic rhinitisanxiety disorderArticleasthmacombined symptom medication scorecontrolled studycross-sectional studydaily life activitydata analysisdepressiondisease associationEuropean Quality of Life 5 Dimensions 5 Level questionnairefemalehumanmajor clinical studymalepainpractice guidelinequality of lifequestionnairerespiratory tract disease assessmentself careself reportvery elderlyvisual analog scalewalkingwalking difficultyallergic rhinitisasthmahealth statuspainArticle10.1016/j.jaip.2023.08.006