Üçüncü S.I.Karayazi O.Işisaǧ A.2024-07-222024-07-22200916845315http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18738As a well known environmental contaminant, perchlorate inhibits thyroidal iodide uptake and reduces thyroid hormone levels. In zebrafish (Danio rerio) exposed to high concentrations of sodium perchlorate (200, 350 and 500 mg/L) for 10 days, remarkable angiogenesis was identified, not only histopathologically but also statistically by counting of the small, medium and large sized (grades 1 to 3) vessels per unit area. Angiogenic response is concluded as the most sensitive parameter for rating of high concentrations of perchlorate exposure. © 2009 Academic Journals.EnglishDanio reriosodium perchlorateangiogenesisanimal experimentanimal tissuearticlecontrolled studyhistopathologyhyperplasiamalenonhumanquantitative analysisthyroid glandzebra fishArticle