Eroglu E.Kurbanoglu S.Polatoglu İ.2025-04-102025-04-102024http://hdl.handle.net/20.500.14701/44287The rapid spread of COVID-19 has led to an unpredicted demand for a rapid, sensitive, and easy-to-use home test in diagnosing and preventing COVID-19. Currently, RT-PCR, which relies on the amplification of virus-specific nucleic acid, is the gold standard technique widely used worldwide owing to its superior specificity and sensitivity compared with tests based on the detection of antigens or antibodies. Despite its widespread use, this test requires a well-equipped laboratory, suboptimal portability, low throughput, expensive supplementary materials, onsite technician expertise, and an extended analysis time. Due to these limitations, RT-qPCR is not readily adaptable as point-of-care testing. SARS-CoV-2 was detected with various rapid diagnostic techniques from the virus's different characteristics, mainly on the surface and inside of the virus such as protein antigens and nucleic acid. Nanozymes are nanomaterials with intrinsic enzyme-like activities, can be used to detect specific biomolecules associated with the target pathogen. Nanozyme-based tests for rapid diagnosis of SARS-CoV-2 have become a promising and innovative approach because of their high stability, enhanced sensitivity, rapid response times, low cost, and tunable catalytic activity in contrast to natural enzymes. In this chapter, nanozyme-based rapid tests are discussed. The latest research has been reviewed, and current challenges along with future perspectives on developing nanozyme-based tests for rapid diagnosis of SARS-CoV-2 are discussed. © 2024 Elsevier Inc. All rights are reserved including those for text and data mining AI training and similar technologies.Book chapter10.1016/B978-0-443-13788-4.00006-6