Batum, MAk, AKAri, MSSelçuki, D2024-07-182024-07-181823-6138http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3127Background & Objective: Cognitive impairment is one of the non-motor symptoms impairing life quality in idiopathic Parkinson's disease (PD) and multiple system atrophy (MSA). In our study, both groups' possible cognitive impairments were evaluated and compared, and the relationship between cognitive profile and motor, non-motor scores, and disease duration was evaluated. Methods: Fifty two PD, 18 MSA, 30 healthy controls were included in the study. Demographic information, scores of Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Questionnaire (PDQ), Addenbrooke's Cognitive Examination-Revised (ACE-R), and Frontal Assessment Battery (FAB) tests were recorded. In addition to the ACE-R test's total scores, sub-scores measuring attention-orientation, memory, verbal fluency, language, and visual-spatial abilities were also evaluated. Results: There was no difference between the groups in age, gender, years of education, and levodopa dose in treatment (p> 0.05). In the inter-group comparison, FAB, ACE-R total, ACE-R sub-scores and PDQ values were significantly different (p <0.05). Significant impairment was found in FAB, ACE-R total, memory, verbal fluency, speaking, and PDQ scores in PD and in all tests in MSA compared to the control group (p <0.05). All tests except memory were more impaired in the MSA group than the PD group. The motor scores in PD showed a strong correlation with FAB, ACE-R total, visual-spatial abilities, speaking, and PDQ scores, whereas motor scores in MSA only correlated poorly with PDQ scores. Conclusion: MSA progressing with multi-systemic involvement showed worse cognitive performance than PD in executive functions and visual-spatial functions, regardless of the disease duration.EnglishArticle