Saribas G.S.Erdogan D.Goktas G.Akyol S.N.Hirfanoglu I.M.Gurgen S.G.Coskun N.Ozogul C.2024-07-222024-07-22201601443615http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15593The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin. © 2016 Informa UK Limited, trading as Taylor & Francis Group.EnglishAcetylcarnitineAnimalsAntineoplastic AgentsCisplatinFallopian TubesFemaleProtective AgentsRatsRats, WistarVitamin B Complexcaspase 3caspase 8caspase 9cisplatinlevacecarnineacetylcarnitineantineoplastic agentcisplatinprotective agentvitamin B complexadultanimal cellanimal experimentanimal modelanimal tissueArticlebody weightcontrolled studyFallopian tubefemaleimmunohistochemistryimmunoreactivitylymphocytenonhumanpriority journalprophylaxisprotein expressionratsecretory celltoxicityTUNEL assayuterine tube diseaseuterine tube toxicityweight reductionWistar ratanimaldrug effectspathologyArticle10.1080/01443615.2016.1209174