Kaçar Döger F.Hekimgil M.Ertan Y.Sarsik B.Soydan S.Neşe N.2024-07-222024-07-22200913000292http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18820Objective: Leukemias and non-Hodgkin lymphomas commonly involve the spleen or originate primarily in the spleen and then spread to other sites. Material and Methods: In this retrospective study, we examined the histopathological and immunohistochemical characteristics of 32 cases of primary or secondary splenic B-cell lymphoma and leukemia, in which the diagnosis was established according to the World Health Organization (WHO) classification. The immunohistochemical panel included ALK-1, BCL-2, BCL-6, CD3, CD5, CD10, CD20, CD21, CD23, CD30, CD43, cyclin D1, Ki-67, and TRAP. Results: There was no other nodal or extranodal disease involvement in the majority of patients diagnosed with lymphoma at the time of presentation, while cases of leukemia had undergone splenectomy for palliative purposes. The diagnoses were as follows: 11 cases of hairy cell leukemia (HCL, 34.4%), 8 cases of splenic marginal zone lymphoma (SMZL, 25%), 8 cases of diffuse large B-cell lymphoma (DLBCL, 25%) including 1 T-cell-rich B-cell lymphoma (TCRBCL), 4 cases of mantle cell lymphoma (MCL, 12.5%), and 1 prolymphocytic leukemia (PLL, 3.1%). Conclusion: Overall assessment of spleen, liver, bone marrow, and lymph node examinations and a detailed correlation of the histopathological and immunohistochemical features with the clinical findings are very helpful and usually lead to the final diagnosis in most cases of primary or secondary splenic B-cell lymphoma and leukemia. Copyright © 2009 by Türkiye Klinikleri.Englishactivin receptor like kinase 1CD20 antigenCD23 antigenCD3 antigenCD30 antigenCD5 antigencommon acute lymphoblastic leukemia antigencomplement component C3d receptorcyclin D1fludarabineKi 67 antigenleukosialinprotein bcl 2protein bcl 6adultagedarticleB cell lymphomabone marrowcancer classificationcancer diagnosiscancer palliative therapyclinical articleclinical assessmentcontrolled studyfemalehairy cell leukemiahistopathologyhumanhuman tissueimmunohistochemistrylarge cell lymphomaleukemialiverlymph nodelymph node metastasismalemantle cell lymphomaprolymphocytic leukemiaretrospective studyspleensplenectomysplenic b cell lymphomasplenic leukemiasplenic marginal zone lymphomat cell rich b cell lymphomaworld health organizationArticle