Sota J.Guerriero S.Lopalco G.Tufan A.Ragab G.AlMaglouth I.Govoni M.Sfikakis P.P.Frassi M.Vitale A.Kardas R.C.Triaggianese P.Chimenti M.S.Aboabat A.A.Piga M.Monti S.Sebastiani G.D.Yildirim D.Conforti A.Gentileschi S.Dammacco R.Hinojosa-Azaola A.Kawakami-Campos P.A.Ruffilli F.Torres-Ruiz J.Thabet M.Atig A.Ruscitti P.Cataldi G.Viapiana O.Hatemi G.Karakoç A.Costi S.Iagnocco A.Crisafulli F.Fragoulis G.Del Giudice E.Hegazy M.T.Paroli M.P.Şahin A.Morrone M.Iannone F.Opris-Belinski D.Asfina K.N.Barone P.Gaggiano C.Kucuk H.Gicchino M.F.Carubbi F.Caggiano V.Laskari K.Tharwat S.Direskeneli H.Alibaz-Oner F.Sevik G.Maier A.Laymouna A.H.Emmi G.Akkoç N.Tarsia M.Sbalchiero J.Conti G.Spinella R.La Torre F.Tombetti E.Amin R.H.Mauro A.Karamanakos A.Carreño E.Fonollosa A.Cattalini M.Breda L.de-la-Torre A.Wiesik-Szewczyk E.Cifuentes-González C.Ozen S.Mazzei M.A.Tosi G.M.Frediani B.Balistreri A.Batu E.D.Gupta V.Cantarini L.Fabiani C.2024-07-222024-07-22202409273948http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11652Purpose: The clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Behçet’s disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown. Methods: Data were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time. Results: Records of 213 patients (341 eyes) were analyzed. No differences in complications were observed (p = 0.465). With regard to VA, a significant difference was detected in median BCVA (p = 0.046), which was not maintained after Bonferroni correction (p = 0.060). RV was significantly more prevalent in NIU-affected patients who tested positive for HLA-B51, irrespective of the systemic diagnosis of BD (p = 0.025). No differences emerged in the occurrence of macular edema (p = 0.99). Conclusions: Patients with NIU testing positive for HLA-B51 exhibit an increased likelihood of RV throughout disease course, irrespective of a systemic diagnosis of BD. The rate of complications as well as VA are comparable between NIU cases unrelated to BD testing positive for HLA-B51 and uveitis associated with BD. Therefore, it is advisable to perform the HLA-B typing in patients with NIU or retinal vasculitis, even in the absence of typical BD features. © 2024 Taylor & Francis Group, LLC.EnglishArticle10.1080/09273948.2024.2346815