Şen S.Kızılay D.Ö.Taneli F.Özen Ç.Ertan P.Özunan İ.Yıldız R.Ersoy B.2024-07-222024-07-22202113085727http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13499Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is one of the new biomarkers for detecting acute renal injury. There are studies showing the relationship between NGAL and renal injury in obese children. The aim of this study was to investigate whether urinary levels of NGAL, kidney injury molecule-1, and serum cystatin C are increased in insulin resistance (IR) patients before the development of diabetes. Methods: Cross-sectional, case-controlled study that included non-diabetic obese children and adolescent patients with IR and a non-diabetic obese control group with no IR, who attended a tertiary center pediatric endocrinology outpatient clinic between 2016-2018. Those with diabetes mellitus and/or known renal disease were excluded. NGAL and creatinine (Cr) levels were evaluated in the morning spot urine from all participants. Serum renal function was evaluated. Results: Thirty-six control and 63 IR patients were included in the study, of whom 68 (68.7%) were girls. The mean age of all participants was 13.12±2.64 years and no statistically significant difference was found between the two groups in terms of age or gender distribution. Median (range) spot urinary NGAL (u-NGAL) values in the IR group were significantly higher at 26.35 (7.01-108.7) ng/mL than in the control group at 19.5 (3.45-88.14) ng/mL (p=0.018). NGAL/Cr ratio was also significantly higher in the IR group compared to the control group (p=0.018). Conclusion: Obese pediatric patients with IR were shown to have elevated levels of u-NGAL, a marker of renal injury. u-NGAL examination may show early renal injury before development of diabetes. © 2021 by Turkish Pediatric Endocrinology and Diabetes Society.EnglishAll Open Access; Gold Open Access; Green Open AccessAdolescentBiomarkersCase-Control StudiesChildCross-Sectional StudiesFemaleHepatitis A Virus Cellular Receptor 1HumansInsulin ResistanceKidney DiseasesLipocalin-2MalePediatric Obesitybiological markerC reactive proteincreatininecystatin Cglucosehemoglobin A1chepatitis A virus cellular receptor 1insulinlow density lipoprotein cholesterolneutrophil gelatinase associated lipocalintestosteronethyrotropinthyroxinetriacylglycerolbiological markerHAVCR1 protein, humanhepatitis A virus cellular receptor 1LCN2 protein, humanneutrophil gelatinase associated lipocalinadolescentadultanthropometryArticleblood pressure monitoringbody masscase control studychildcontrolled studycreatinine blood levelcross-sectional studydiabetes mellitusdiastolic blood pressurediet supplementationenzyme linked immunosorbent assayfemalefree thyroxine indexglucose blood levelhomeostasis model assessmenthumaninsulin resistancekidney functionkidney injurymajor clinical studymalemicroalbuminurianeutrophiliaobesityoutpatient departmentprevalenceprotein expressionquestionnairerisk factorurinary tract infectionurine levelchildhood obesityinsulin resistancekidney diseasemetabolismphysiologyurineArticle10.4274/JCRPE.GALENOS.2021.2021.0020