Ersoy B.Eroğlu N.Çetin M.Onur E.Özkol M.Coşkun Ş.2024-07-222024-07-22201814791641http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14989Aims: We aimed to evaluate asymmetric dimethylarginine levels in young patients with Type 1 diabetes mellitus according to diabetes duration and to examine the relationship between these levels and measures of atherosclerosis and myocardial function. Materials and methods: In total, 83 patients (8.5–22 years) with Type 1 diabetes mellitus were stratified by diabetes duration: 12–60 months (Group 1, n = 27), >60–120 months (Group 2, n = 29) and >120 months (Group 3, n = 27). Asymmetric dimethylarginine levels were assessed. Carotid intima–media thickness was measured. Myocardial function was assessed by M-mode, conventional Doppler and tissue Doppler echocardiography. Results: Asymmetric dimethylarginine level was significantly higher in Group 1, while carotid intima–media thickness was significantly greater in Group 3 (p < 0.05). Tissue Doppler echocardiography showed the ratio of peak early to peak late diastolic myocardial annular velocity decreased significantly in Groups 2 and 3 with a negative correlation with duration (r: −0.310, p = 0.004) and HBA1c levels (r = −0.391, p < 0.001). Myocardial performance index in all groups and isovolumic relaxation time in Group 3 increased significantly. Asymmetric dimethylarginine levels were negatively correlated with carotid intima–media thickness and isovolumic relaxation time (p < 0.05). Conclusion: In contrast to adult diabetics, asymmetric dimethylarginine concentration decreases as diabetes duration increases in young Type 1 diabetic patients and is associated with worsening measures of cardiovascular risk and poorer diastolic function. © 2018, © The Author(s) 2018.EnglishAll Open Access; Bronze Open AccessAdolescentAdultArginineAtherosclerosisCarotid Intima-Media ThicknessChildDiabetes Mellitus, Type 1EchocardiographyEchocardiography, DopplerFemaleHumansMaleMyocardiumVentricular Function, LeftYoung Adulthemoglobin A1cn(g),n(g) dimethylargininearginineN,N-dimethylarginineadolescentadultamino acid blood levelarterial wall thicknessArticleatherosclerosiscardiovascular riskchildcontrolled studycross-sectional studydisease associationdisease coursedisease durationfemaleheart contractionheart functionhumaninsulin dependent diabetes mellitusmajor clinical studymalerelaxation timetissue Doppler imaginganalogs and derivativesatherosclerosisbloodcardiac musclecomplicationDoppler echocardiographyechocardiographyheart left ventricle functioninsulin dependent diabetes mellitusmetabolismproceduresyoung adultArticle10.1177/1479164118757921