Synthesis and characterization of chloralose-derived thiosemicarbazones and semicarbazones and investigation of their antimicrobial properties

Yetgin C.E.Oskay M.Ay K.2025-04-102025-04-102014http://hdl.handle.net/20.500.14701/49579Thiosemicarbazones(7-10)/semicarbazones(11-14) were synthesized in good yields via the condensation of α-gluco-, β-gluco-, galacto-, manno- chloralose derived 1,4-furanodialdoses (1-4) with thiosemicarbazide(5)/ semicarbazide(6). The structures of all products were characterized by FTIR, NMR spectroscopic methods and elemental analysis. The compounds have been found to display moderate antimicrobial activity against Gram-positive, Gram-negative bacteria and antifungal activity against a Candida albicans. MIC values of the compounds range from 260 to 1510 g/mL. © 2014 Taylor & Francis Group, LLC.Synthesis and characterization of chloralose-derived thiosemicarbazones and semicarbazones and investigation of their antimicrobial propertiesArticle10.1080/07328303.2014.913060