Tatlici T.K.Cetin N.Korpe B.Kose C.Korkmaz V.2024-07-222024-07-22202401044230http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11608OBJECTIVE: The aim of this study was to evaluate the relationship between uterine leiomyoma and fragmented QRS, a non-invasive indicator of cardiovascular risk and myocardial ischemia, in women with uterine leiomyoma. METHODS: In this prospective case-control study, a total of 47 patients diagnosed with uterine leiomyoma (case group) and 47 healthy individuals without uterine leiomyoma (control group) who had undergone bilateral tubal ligation surgery were included. Various demographic, clinical, and laboratory parameters and the presence of fragmented QRS were recorded. RESULTS: The leiomyoma group showed significantly higher body mass index (27.46±2.18 vs. 25.9±2.87 kg/m2, p=0.005) and waist circumference (91.34±9.30 vs. 84.97±9.3 cm, p=0.001) compared with the control group. Uterine volumes were also significantly higher in the leiomyoma group (235.75±323.48 vs. 53.24±12.81 mm3, p<0.001). The presence of fragmented QRS was detected in 18.1% of the patients. Multiple regression analysis identified age, fasting blood glucose value, and the presence of fragmented QRS as independent risk factors for the presence of leiomyoma. CONCLUSION: This study provides valuable insights into the relationship between uterine leiomyoma and fragmented QRS. The presence of fragmented QRS was identified as an independent risk factor for the presence of leiomyoma. Further research is needed to better understand the underlying mechanisms connecting uterine leiomyoma and cardiovascular health. © 2024 Associacao Medica Brasileira. All rights reserved.EnglishAll Open Access; Gold Open AccessAdultBody Mass IndexCase-Control StudiesElectrocardiographyFemaleHumansLeiomyomaMiddle AgedMyocardial IschemiaProspective StudiesRisk FactorsUterine Neoplasmsalanine aminotransferaseaspartate aminotransferasecholesterolcreatinineestradiolfollitropinglucosehemoglobinhemoglobin A1chigh density lipoprotein cholesterolinsulinlow density lipoprotein cholesterolluteinizing hormonetriacylglycerolvery low density lipoprotein cholesterolabdominal circumferenceadultArticleblood cell countbody masscardiovascular riskcase control studycesarean sectionclinical articleclinical trialcohort analysiscontrolled studyelectrocardiographyendometrial thicknessfemaleglucose blood levelheart muscle ischemiaheart ratehematocrithomeostasis model assessmenthumanleiomyomaleukocyte countparityphysical examinationplatelet countpregnancyprospective studyQRS intervalrisk factorurea nitrogen blood leveluterine tube ligationuterus myomawaist circumferencecomplicationelectrocardiographyleiomyomamiddle agedpathophysiologyprospective studyuterus tumorArticle10.1590/1806-9282.20231359