Pirildar T.Gumuser G.Ruksen E.Sakar A.Dinc G.Sayit E.2024-07-222024-07-22201001728172http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18411Sjögren's syndrome (SjS) is a systemic autoimmune disease that mainly affects the exocrine glands and usually presents as persistent dryness of the mouth and eyes. Lung disease in SjS has been reported to occur early following clinical presentation of the disease. In this study, technetium-99m diethylene triamine penta-acetic acid (Tc-99m DTPA) aerosol inhalation scintigraphy was used to assess the pulmonary membrane permeability in patients with primary SjS. A total of 18 patients with primary SjS and 13 healthy controls were investigated. Clinical evaluation, chest X-ray examination, pulmonary function tests, Tc-99m DTPA aerosol scintigraphy were performed in all the cases. The presence of respiratory symptoms (dyspnea and cough), duration of sicca symptoms were recorded. The clearance half time of Tc-99m DTPA radioaerosols in patients with SjS (20.49 ± 2.56 min) was faster when compared to normal controls (42.32 ± 13.28 min) (P = 0.000) which means that there is a significant increase in lung permeability in patients with SjS compared to the controls. There is also a significant difference between PI of patients with SjS (0.34 ± 0.09) and that of controls (0.42 ± 0.07) (P = 0.012). According to the results of our preliminary study, one can detect pulmonary involvement by Tc-99m DTPA aerosol inhalation scinti-graphy in patients with primary SjS. © Springer-Verlag 2009.EnglishAdministration, InhalationAdultAerosolsCase-Control StudiesCell Membrane PermeabilityFemaleHumansMaleMiddle AgedPilot ProjectsPredictive Value of TestsPulmonary AlveoliRadiography, ThoracicRadiopharmaceuticalsRespiratory Function TestsRespiratory MucosaSjogren's SyndromeTechnetium Tc 99m Pentetatepentetate technetium tc 99madultaerosolagedarticlecell membrane permeabilityclinical articleclinical evaluationcontrolled studycoughingdrug clearancedrug half lifedyspneafemalehumanlung alveolus epitheliumlung diseaselung function testlung scintiscanningmalepriority journalSjoegren syndromethorax radiographyxerostomiaArticle10.1007/s00296-009-1023-3