Kaba M.Pirinççi N.Yüksel M.B.Geçit I.Güneş M.Demir M.Akkoyun H.T.Demir H.2024-07-222024-07-22201516775538http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16462Introduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9±11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4±10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20°C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.EnglishAll Open Access; Gold Open Access; Green Open AccessAdolescentAdultBiomarkers, TumorCase-Control StudiesHumansMaleNeoplasms, Germ Cell and EmbryonalReference ValuesRisk FactorsSpectrophotometry, AtomicStatistics, NonparametricTesticular NeoplasmsTrace ElementsYoung Adulttrace elementtumor markeradolescentadultatomic absorption spectrometrybloodcase control studyhumanmaleNeoplasms, Germ Cell and Embryonalnonparametric testpathologyreference valuerisk factorTesticular Neoplasmsyoung adultArticle10.1590/S1677-5538.IBJU.2014.0460