Kutbay N.O.Yurekli B.S.Simsir I.Y.Suner A.Seckiner S.Kucukerdonmez O.Saygili F.2024-07-222024-07-2220190172780Xhttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14595OBJECTIVE: The aim of this study was to compare antioxidant Vitamin C and Vitamin E levels in the non-acromegaly control group and in patients with acromegaly with and without remission. MATERIAL AND METHODS: In this study, 100 cases, acromegaly patients of 57% (n=57, 29F, 28M, mean ages of 49.5±12.1) and control subjects of 43% (n=43, 29F, 14M, mean ages of 49.6±9.2). Acromegaly patients were classified into two groups; active acromegaly (AA; n=33) and controlled acromegaly (CA; n=24). RESULTS: Vitamin C levels were significantly lower in the acromegaly group [7.6 (4.7) mg/L, as median (IQR)] when compared to the control group [12.2 (5.5) mg/L, as median (IQR)] (p <0.001). Vitamin E levels didn't show a significant difference between the acromegaly and the control groups (14.2±3.6 vs. 14.8±3.7, as mean±SD, respectively, p = 0.439). Correlation analysis showed that Vitamin C levels were not significantly associated with clinical, anthropometric and laboratory parameters in the acromegaly group. Vitamin E levels were significantly associated with the total cholesterol, triglyceride, LDL-C, HDL-C, APO Al, APO B both in the acromegaly and the control groups. CONCLUSION: This study is the first one to investigate the relationship between the levels of Vitamin C & E and anthropometric & metabolic parameters in acromegaly patients and control group. In our study, Vitamin C level was significantly lower in the acromegaly group compared to the level in the control group. There was no significant difference in Vitamin E levels between the acromegaly and control group. © 2019 Maghira and Maas Publications. All rights reserved.EnglishAcromegalyAdipose TissueAdultApolipoprotein A-IApolipoproteins BAscorbic AcidBody CompositionBody Mass IndexCase-Control StudiesCholesterolCholesterol, HDLCholesterol, LDLElectric ImpedanceFemaleHuman Growth HormoneHumansInsulin ResistanceInsulin-Like Growth Factor IMaleMiddle AgedReceptors, SomatotropinTriglyceridesVitamin EWaist Circumferencealpha tocopherolapolipoprotein A1apolipoprotein Bascorbic acidcholesterolhigh density lipoprotein cholesterollow density lipoprotein cholesterolpegvisomanttriacylglycerolalpha tocopherolapolipoprotein A1apolipoprotein Bascorbic acidcholesterolgrowth hormone receptorhigh density lipoprotein cholesterolhuman growth hormonelow density lipoprotein cholesterolpegvisomantsomatomedin Ctriacylglycerolacromegalyadultanthropometric parametersArticlecase control studycholesterol blood levelclinical featurecontrolled studycorrelation analysisdiabetes mellitusdisease durationfemaleglucose intolerancehigh performance liquid chromatographyhumanhypertensionimpaired glucose toleranceimpedancelaboratory testmajor clinical studymalemedical historymetabolic parameterspatientremissionsmokingtriacylglycerol blood levelvitamin blood levelacromegalyadipose tissuebloodbody compositionbody massinsulin resistancemetabolismmiddle agedwaist circumferenceArticle