Temeltas, GMuezzinoglu, TAkar, ZLekili, MBüyüksu, C2024-07-182024-07-182149-32352149-3057http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3180Introduction: It is evaluated that endocrinolgical effect is the most reliable factor for development of histological and clinical BPH which is the common disease in older males. Materials and Methods: In our study, we investigated the relationship between BPH incidence and steroid hormone levels by using the criteria of I-PSS, residual urine and prostatic volume in the men over 40 in a rural town. Total and free testosterone, estradiol, dihidroepiandosteron sulfate, sex hormone binding globulin, FSH and LH levels were analyzed. I-PSS and quality of life scores were evaluated. Results: Mean FSH, LH, DHEAS, SHBG, E2, tT and fT levels were 11.03 +/- 11.06 mIU/ml (0.9-83.7), 9.26 +/- 18.7 mIU/ml (0.7-200), 114, 86 +/- 68.3 pg/dl (30-417), 55.28 +/- 31.4 nmol/L (2-180), 23.03 +/- 9.05 pg/mL (2046.1), 3.9 +/- 1.82 ng/dl (0.2-16) and 13.7 +/- 4.7 pg/mL (0.6-31.6). Mean I-PSS, QoL, residual urine and prostatic volume were 4.7 +/- 5.9 (0-30), 0.7 +/- 1.3 (0-6), 21.5 +/- 30.7 (0-295) ml and 24.4 +/- 11.4 (9-82) gr. respectively. With Pearson correlation system; age, I-PSS, QoL, residual urine and prostatic volume were well correlated with each other (p<0.05). While age increased, FSH and SHBG increased significantly (r=0.2979 and r=0.3642). On the other hand, DHEAS ( r=-0.4792) and fT (r=-0.3306) decreased, while age increased. There was no correlation between E2, LH, tT, SHBG and age. When it is accepted as all the men with their I-PSS over 7 has BPH; fT levels were statistically lower (14/12.3, p=0.009) and their SHBG levels were higher than those without BPH (52.5/64.8, p=0.029). Conclusion: If the diagnosis of BPH is determined with the different combination of I-PSS, residual urine and prostatic volume, no significant data was revealed between serum steroid hormone levels and BPH. fT levels were significantly lower in men with high I-PSS than those with low I-PSS.TurkishArticle