Kaya E.Aydemir O.Selçuki D.2024-07-222024-07-22200913026631http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18699Objective: In bipolar disorder, both cognitive and social functioning is impaired during remission. It is not well documented whether residual affective symptoms cause impairment in cognitive and social functions or cognitive impairment per se is the source of psychosocial dysfunction during remission. In this work, the effects of subsyndromal residual affective symptoms on cognitive and social functioning in remitted bipolar patients are studied. Materials and Methods: The study was carried out with 43 patients diagnosed as bipolar I disorder with a remission for at least 6 months. The mean age of the patients was 38.1±13.5 and 55.8% (n=24) were male. The mean duration of illness was 12.1±10.2 years and the mean number of previous episodes was 6.6±6.0. As healthy controls, 22 volunteers without any lifetime psychiatric and medical diagnosis or treatment were invited to the study. In the assessment Hamilton Depression Rating Scale (HAM-D), Young Mania Rating Scale (YMRS), Stroop Test, Auditory Verbal Learning Test (AVLT), increased latency positive-evoked potentials (P300), Global Assessment of Functioning Scale (GAF), and Social Functioning Scale (SFS) were used. In statistical analyses, linear regression analysis was performed. Results: HAM-D scores significantly affected cognitive functions such as P300 amplitude, immediate recall, verbal learning, delayed recall, recognition, retrieval, Stroop effect, and social functions such as social engagement, interpersonal behavior, prosocial activities, recreation, independence-performance and competency and employment. YMRS scores affected only verbal learning. Cognitive functions do not have any effect on mood symptoms or social functions. Discussion and Conclusion: Subsyndromal residual depressive symptoms seem to affect functioning in remitted bipolar patients. In order to improve the functioning of the bipolar patients, it will be helpful to implement strategies for these depressive symptoms.Turkishadultarticlebipolar depressionbipolar I disorderclinical articlecognitioncontrolled studydisease durationemploymentevent related potentialfemaleHamilton scalehumanindependencelearninglong term memorymalerecreationremissionshort term memorysocial behaviorsocial competencesocial interactionvolunteerYoung Mania Rating ScaleArticle