Gündüz C.Taşbakan M.S.Sayiner A.Çilli A.Kilinç O.Şakar Coşkun A.2024-07-222024-07-22201613000144http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16033Background/aim: Treatment failure in hospitalized patients with community-acquired pneumonia is a major cause of mortality. The aim of this study was to evaluate the factors affecting treatment success in community-acquired pneumonia. Materials and methods: A total of 537 patients (mean age: 66.1 ± 15.8 years, 365 males) registered to the Turkish Thoracic Society Pneumonia Database were analyzed. Of these, clinical improvement or cure, defined as treatment success, was achieved in 477, whereas 60 patients had treatment failure and/or died. Results: Lower numbers of neutrophils (5989.9 ± 6237.3 vs. 8495.6 ± 7279.5/mm3), higher blood urea levels (66.1 ± 42.1 vs. 51.2 ± 38.2 mg/dL), higher Pneumonia Severity Index (PSI) scores (123.3 ± 42.6 vs. 96.3 ± 32.9), higher CURB-65 scores (2.7 ± 1.2 vs. 2.2 ± 0.9), lower PaO2/FiO2 ratios (216.3 ± 86.8 vs. 269.9 ± 65.6), and the presence of multilobar (33.3% vs. 16.4%) and bilateral (41.7% vs. 18.9%) radiologic infiltrates were related to treatment failure. The PSI score and PaO2/FiO2 ratio were independent parameters affecting treatment results in multivariate linear regression analysis (P < 0.001). Conclusion: The risk of treatment failure is high in patients with severe pneumonia and with respiratory failure. Effective treatment and close monitoring are required for these cases. © TÜBİTAK.EnglishAll Open Access; Bronze Open AccessAgedAged, 80 and overCommunity-Acquired InfectionsFemaleHumansMaleMiddle AgedMultivariate AnalysisPneumoniaPrognosisSeverity of Illness IndexTreatment OutcomealbuminC reactive proteinprocalcitoninagedantibiotic therapyarterial oxygen tensionArticlebacterial pneumoniabreathing ratecommunity acquired pneumoniafemalehospitalizationhumanleukocyte countmajor clinical studymalemortality rateneutrophil countpleura effusionPneumonia Severity Indexrespiratory failureretrospective studytreatment failureurea nitrogen blood levelcommunity acquired infectionmiddle agedmultivariate analysispneumoniaprognosisseverity of illness indextreatment outcomevery elderlyArticle10.3906/sag-1502-87