Gunes, MKemik, ASPirincci, NGecit, ITaken, KYuksel, MBKaba, MEryilmaz, R2024-07-182024-07-181513-7368http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10087Our aim was to test the hypothesis that preoperative serum levels of matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels correlate with pathological features. Serum levels of MMP-7, and MMP-9 and TIMP-1 were determined in 90 bladder cancer patients and 40 healthy controls using an enzyme linked immunosorbent assay. Preoperative serum MMP-7 and MMP-9 levels were significantly higher in cancer patients than control groups (p<0.001). In contast, serum TIMP-1 levels were lower (p<0.001). Alteration in MMP-7, and MMP-9, and TIMP-1 production may contribute to tumor angiogenesis and be associated with clinic-pathological features.EnglishSERUM-LEVELSCANCERMATRIX-METALLOPROTEINASE-9EXPRESSIONSURVIVALMMP-9METASTASISPREDICTSTIMP-1DIAGNOSISArticle