Gündüz K.Günay Ü.Inanir I.Gençoǧlan G.Temiz P.2024-07-222024-07-22201218987249http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17482Background: The classic Kaposi sarcoma is most common in the Mediterranean po-pulation over 50 years of age and presents with reddish-brown papules and nodules particularly on the lower limbs. Treatment depends on the clinical presentation and extension of lesions. Imiquimod is as an immune response modifier with antiangio-genic activity. Main observations: We present a 74-year-old man with classic Kaposi sarcoma who had multiple, small, violaceous papules and nodules on the trunk and extremities with a history of 14 years. He complained particularly from plantar hyperkeratotic painful nodules. Treatment with imiquimod 5% cream under occlusion resulted with almost complete regression within 12 weeks. No local or systemic side effects were observed. Conclusions: Topical imiquimod was a safe and effective therapy in our patient with classic Kaposi sarcoma.EnglishAll Open Access; Green Open Accessimiquimodagedarticlecase reportdrug efficacyfollow uphisopathologyhumanhuman tissueKaposi sarcomamalepapuleskin noduletumor regressionArticle10.3315/jdcr.2012.1099