Yilmaz O.Yuksel H.2024-07-222024-07-22201687556863http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15597Airway remodeling is the chronic outcome of inflammation in asthma and a point of intervention between pediatric and adult ages. Pediatric asthma has been of great interest in the efforts to find a valuable time to interrupt remodeling. Various experimental and clinical research have assessed the effect of current therapeutic modalities on airway remodeling in asthma and many new agents are being developed with promising results. The heterogeneity in the results of these studies may lie in the heterogeneity of pathogenesis leading to asthma and remodeling; underlying the need for individualized treatment of the unique pathogenetic characteristics of each child's asthma. The aim of this review is to summarize the evidence about the influence of current and future therapeutic modalities in the concept of inflammation and remodeling in pediatric asthma. Pediatr Pulmonol. 2016;51:1422–1429. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.EnglishAdministration, InhalationAdolescentAdrenal Cortex HormonesAirway RemodelingAnti-Asthmatic AgentsAntibodies, Monoclonal, HumanizedAsthmaBronchodilator AgentsCalcium Channel BlockersChildChild, PreschoolCytokinesHumansInfantInflammationInterleukin-5Leukotriene AntagonistsOmalizumabTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AVitamin DVitaminsbeta adrenergic receptor stimulating agentcalcitriolcalcium channel blocking agentcytokine antibodydexamethasoneinterleukin 13 antibodyinterleukin 4 antibodyinterleukin 5 antibodyinterleukin 9 antibodyipratropium bromidemontelukastomalizumabplasminogen activator inhibitor 1reslizumabsteroidtiotropium bromidetumor necrosis factor antibodyunclassified drugvasculotropin inhibitorantiasthmatic agentbronchodilating agentcorticosteroidcytokineinterleukin 5leukotriene receptor blocking agentmepolizumabmonoclonal antibodytumor necrosis factorvasculotropin Avitaminvitamin Dairway ultrastructureasthmaclinical effectivenessdrug efficacyhumaninflammationpathogenesispriority journalReviewsteroid therapyadolescentairway remodelingantagonists and inhibitorsasthmachildimmunologyinfantinflammationinhalational drug administrationpathophysiologyphysiologypreschool childReview10.1002/ppul.23488