Kaya N.Koçer B.Devrim A.K.2024-07-222024-07-22201200154725http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17619Twenty Tuj sheep weighing 31±2 kg were investigated for the effect of chronic fluorosis on their serum parathyroid hormone (PTH) and calcitonin (CT) activity levels. For a period of 9 months, ten of the sheep were exposed to 4 ppm NaF (1.8 ppm F ion) in their drinking water to induce fluorosis. During the study, urinary pH gradually increased from 7.2 to 7.9. In the first 12 weeks, urinary fluoride showed a small increase from 0.9 to 1.2 ppm, but by week 38 at the end of the experiment it had risen to 16 ppm, and the serum PTH levels had decreased (p<0.01), whereas the CT levels had increased (p<0.01) compared to the control group. © 2012 The International Society for Fluoride Research Inc.EnglishOvis ariescalcitonindrinking waterfluorideparathyroid hormoneanimal experimentanimal modelarticlebody weightcalcitonin blood levelchronic diseasecontrolled studyfluorosishormone determinationnonhumanparathyroid hormone blood levelsheepurine levelurine pHArticle