Sohrabi M.Soleimani J.Roshangar L.Vatansever S.Arbabi F.Khaki A.A.Abbasi M.M.Dustar Y.Javadzadeh Y.2024-07-222024-07-22200900309982http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18578Objective: To compare the preventive effect of dietary and topical Celecoxib (CCB), a potent inhibitor of COX-2 on 4-NQO-induced tongue SCC in rat. Methods: Fifty male Sprague Dawley adult 3- 3.5 months old rats were used as animal model in this study. The tongue SCC was induced by a daily administration of 30 ppm 4-NQO, in drinking water, for 8 months. The rats in case groups received dietary or topical CCB. Tongue Specimens were prepared for histopathological and immunohistochemical (Ki-67) staining and or TUNEL assay were examined. Values are expressed as mean ± SEM and analyzed with Npar Kruscal Wallis and one-way ANOVA tests. p < 0.05 was considered significant. Results: The incidence of tongue precancer lesions, judged by morphological and morhometrical criteria and apoptosis/proliferation ratio, was significantly (p<0.01) reduced by CCB. The effect of topical CCB use, at high doses, was comparable to the effect of dietary CCB. Conclusion: Both topical and dietary CCB have inhibitory effect on 4-NQO induced SCC on tongue. The effect of CCB is probably mediated by suppression of cell proliferation and induction of apoptosis.English4-Nitroquinoline-1-oxideAdministration, TopicalAnalysis of VarianceAnimalsCyclooxygenase InhibitorsDietDisease Models, AnimalIn Situ Nick-End LabelingMalePrecancerous ConditionsPyrazolesRatsRats, Sprague-DawleySulfonamidesTongueTongue Neoplasms4 nitroquinoline 1 oxidecelecoxibdrinking wateragedanimal experimentanimal modelanimal tissueapoptosisarticlecancer incidencecell proliferationcontrolled studydrug effectfluid intakefood intakehistopathologyimmunohistochemistrymalenick end labelingnonhumanratscanning electron microscopytongue carcinomaArticle