Rahman, BDeliormanli, AMAtmaca, H2024-07-182024-07-181574-14431574-1451http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/5033Silicate-based bioactive glasses doped with Er3+ and Tb3+ ions (1, 3, and 5 wt%) were synthesized in the form of powders and nanofibers using sol-gel and electrospinning methods, respectively. In vitro bioactivity of the prepared powders and fibers was analyzed in simulated body fluid (SBF) for various periods, and the biological response of the osteoblastic MC3T3-E1 cells to the bioactive glass samples was studied using MTT assay and microscopic observations. The amoxicillin release behavior of the prepared glasses was examined in phosphate-buffered saline as a function of time. The results revealed that the incorporation of Er3+ and Tb3+ improved the hydroxyapatite forming ability of the prepared bioactive glass samples for up to 30 d of immersion in SBF. In vitro cytotoxicity experiments showed that Tb3+-containing glass samples were biocompatible at all concentrations; however, in the case of Er3+-containing glass particle-based samples, a decrease in cell viability was observed starting from 3 wt% Er3+. SEM observations revealed cellular adhesion and spreading on the bioactive glass scaffolds. Drug delivery experiments demonstrated that after 24 h, similar to 35 to 38% of the drug was released into the medium for both bioactive glass powder and nanofiber-based samples. Bioactive glasses synthesized in the study have the potential to be used in bone tissue engineering applications.EnglishSCAFFOLDSDELIVERYNANOPARTICLESAMOXICILLINArticle