Bayindir P.Yilmaz Ovali G.Pabuşçu Y.Temiz C.Duruoz T.2024-07-222024-07-22200607703198http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19535Ochronosis is a rare hereditary disorder of tyrosine metabolism. Severe degenerative arthritis and spondylosis occur in the later stages of this disease. Radiologic examinations may reveal changes considered almost pathognomonic for ochronosis. We present the radiologic features of the lumbar spine in two ochronotic patients who were diagnosed after radiologic examinations in the late stages of the disease. © Clinical Rheumatology 2005.EnglishDisease ProgressionFemaleHumansLumbar VertebraeMagnetic Resonance ImagingMaleMiddle AgedOchronosisOsteoporosisTomography, X-Ray Computedhomogentisic acidadultarticlecalcificationcase reportclinical featurecomputer assisted tomographydiffusion weighted imagingdisease severityexternal earfemalegenetic disorderhumanimage analysisintervertebral diskintervertebral disk hernialimb weaknesslow back painlumbar disk hernialumbar spinemalenuclear magnetic resonance imagingochronosisosteoarthritisosteoporosispriority journalradiodiagnosisskin discolorationspine radiographyspondylosisurinalysisArticle10.1007/s10067-005-0033-0