Akin Ocal F.C.Kesici G.G.Gurgen S.G.Ocal R.Erbek S.2024-07-222024-07-22201900222151http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14466Objective To investigate whether oxytocin can prevent ototoxicity related to acoustic trauma.Methods Twenty-eight rats were divided into four groups: Noise (group 1), control (group 2), noise plus oxytocin (group 3), and oxytocin (group 4). Intratympanic oxytocin was administered on days 1, 2, 4, 6, 8 and 10 in groups 3 and 4. Groups 1 and 3 were exposed to acoustic trauma. Distortion product otoacoustic emission and auditory brainstem response testing were performed in all groups.Results In group 1, auditory brainstem response thresholds increased significantly after acoustic trauma. In group 3, auditory brainstem response thresholds increased significantly on day 1 after acoustic trauma, but there were no significant differences between thresholds at baseline and on the 7th and 21st days. In group 1, significant differences were observed between distortion product otoacoustic emission signal-to-noise ratios measured before and on days 1, 7 and 21 after acoustic trauma. In group 3, no significant differences were observed between the distortion product otoacoustic emission signal-to-noise ratios measured before and on days 7 and 21 after acoustic trauma.Conclusion Oxytocin had a therapeutic effect on rats exposed to acoustic trauma in this experiment. © 2019 JLO (1984) Limited.EnglishAnimalsBiopsy, NeedleDisease Models, AnimalEvoked Potentials, Auditory, Brain StemHearing Loss, Noise-InducedImmunohistochemistryInjections, IntralesionalMaleOtoacoustic Emissions, SpontaneousOxytocinRandom AllocationRatsRats, Sprague-DawleyReference ValuesSignal-To-Noise RatioStatistics, NonparametricTreatment OutcomeTympanic Membraneoxytocinsynpitan fortoxytocinanimal experimentanimal modelanimal tissueArticleauditory responsebrain stem responsecochlea tissuecontrolled studydistortion product otoacoustic emissionexternal auditory canalimmunohistochemistrymalenoise injurynonhumanototoxicityratsignal noise ratiotherapy effectwhite noiseanimalcomparative studydisease modeldrug effecteardrumevoked brain stem auditory responseintralesional drug administrationneedle biopsynoise injurynonparametric testpathologyrandomizationreference valuespontaneous otoacoustic emissionSprague Dawley rattreatment outcomeArticle10.1017/S0022215119001014