Gunes M.Kemik A.S.Pirincci N.Gecit I.Taken K.Yuksel M.B.Kaba M.Eryilmaz R.2024-07-222024-07-22201315137368http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17568Our aim was to test the hypothesis that preoperative serum levels of matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels correlate with pathological features. Serum levels of MMP-7, and MMP-9 and TIMP-1 were determined in 90 bladder cancer patients and 40 healthy controls using an enzyme linked immunosorbent assay. Preoperative serum MMP-7 and MMP-9 levels were significantly higher in cancer patients than control groups (p<0.001). In contast, serum TIMP-1 levels were lower (p<0.001). Alteration in MMP-7, and MMP-9, and TIMP-1 production may contribute to tumor angiogenesis and be associated with clinic-pathological features.EnglishAll Open Access; Gold Open Access; Green Open AccessAdultAgedDisease ProgressionFemaleHumansMaleMatrix Metalloproteinase 7Matrix Metalloproteinase 9Middle AgedTissue Inhibitor of Metalloproteinase-1Tumor Markers, BiologicalUrinary BladderUrinary Bladder Neoplasmsgelatinase BmatrilysinMMP7 protein, humanMMP9 protein, humanTIMP1 protein, humantissue inhibitor of metalloproteinase 1tumor markeradultagedarticlebladderbladder tumorblooddisease coursefemalehumanmalemetabolismmiddle agedArticle10.7314/APJCP.2013.14.2.873