Tikiz C.Ütük O.Bayturan O.Bayindir P.Ekmekçi C.Tikiz H.2024-07-222024-07-2220050386300Xhttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19800In this study, we investigated the effects of both 25 and 50 mg daily doses of rofecoxib on the endothelial functions of patients with coronary artery disease (CAD). For this purpose, 34 patients with documented severe CAD and who were under aspirin treatment (300 mg/day) were randomized to receive 4 weeks of treatment with a placebo (n = 10, group I), rofecoxib 25 mg/day (n = 12, group II), and rofecoxib 50 mg/day (n = 12, group III). Brachial artery vasodilator responses were measured in order to evaluate endothelial function. The percentage of change in endothelial-dependent vasodilation in groups I, II, and III were similar at the baseline level and showed no significant change after treatment (6.2 ± 3.9% vs. 5.9 ± 3.1% and 5.8 ± 3.3% vs. 5.6 ± 3.8% and 6.1 ± 4.5% vs. 5.8 ± 4.1%, respectively; P > 0.05). Compared with the baseline, endothelium-independent vasodilatation, as assessed by nitroglycerine (NTG), remained unchanged after the treatment period (11.2 ± 6.9% vs. 10.3 ± 7.1% and 11.2 ± 6.3% vs. 9.9 ± 5.1% and 9.5 ± 4.9% and 8.8 ± 4.6%, respectively; P > 0.05). Treatment with both doses also showed no significant effects on high-sensitivity C-reactive protein (hs-CRP) levels and resting arterial diameters (P > 0.05). In conclusion, 4 weeks of treatment with standard and high doses of rofecoxib showed no significant effects on either endothelial-dependent or independent vasodilator response or plasma hs-CRP levels in patients with severe CAD taking concomitant aspirin. Copyright©2005 by Okayama University Medical School.EnglishAgedBrachial ArteryCoronary ArteriosclerosisCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDose-Response Relationship, DrugEndothelium, VascularFemaleHumansLactonesMaleMembrane ProteinsMiddle AgedNitroglycerinProstaglandin-Endoperoxide SynthasesSulfonesVasodilationVasodilator Agentsacetylsalicylic acidC reactive proteincyclooxygenase 2glyceryl trinitrateplaceborofecoxibadultagedartery diameterarticlebrachial arterycell functionclinical articlecontrolled studycoronary artery diseasedose responsedrug megadoseendotheliumenzyme inhibitionfemalehumanmaleprotein blood levelstatistical significancevasodilatationArticle