Alkan F.Ersoy B.Kızılay D.O.Coskun S.2024-07-222024-07-22202110966374http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13198Introduction: Children with Growth Hormone deficiency (GHD) are prone to heart dysfunction and, if left untreated, will result in marked cardiac dysfunction in adulthood. The aim was to evaluate the effect of GHD and growth hormone (GH) therapy on cardiac structure in children and adolescents, and to investigate the role of insulin like growth factor-1 (IGF-1) in this. Methods: M-mode, pulse-wave Doppler echocardiography and tissue Doppler imaging (TDI) were performed in 49 children with GHD who were divided into those with a peak GH response < 7 μg/L and 7–10 μg/L after two GH stimulation tests, aged 8–16 years at baseline and at six and 12 months after GH initiation, and 49 healthy peers. IGF-1 concentration was measured. Results: Although the left ventricular end diastolic and systolic diameters in both GH deficient groups were significantly lower than controls (p < 0.01), both diameters increased significantly with one year of treatment and achieved normal values (p > 0.05). Using TDI in both two patients group revealed increased E/A, prolonged isovolumic relaxation time, shortened ejection time, and a significant increase in myocardial performance index compared to controls (p < 0.001). Significant improvement was observed in these parameters from the sixth month of GH treatment (p < 0.001), this improvement does not match parameters measured in healthy peers, even after one year of treatment in both patients group. (p < 0.001). No correlation was found between IGF-1 concentration and any echocardiographic parameter. Conclusion: Echocardiographic parameters were similar in children with a GH peak < 7 μg/L and 7–10 μg/L. In TDI, both systolic and diastolic function was impaired in GHD children compared to controls. These parameters improved after one year of GH therapy but did not recover to healthy control levels. © 2021 Elsevier LtdEnglishCardiovascular DiseasesCase-Control StudiesChildDwarfism, PituitaryEchocardiographyFemaleFollow-Up StudiesHormone Replacement TherapyHuman Growth HormoneHumansInsulin-Like Growth Factor IMalePrognosisProspective StudiesRisk Factorsgrowth hormonesomatomedin Chuman growth hormoneIGF1 protein, humansomatomedin CadolescentArticlebody heightbody weightchildclinical articleclinical effectivenesscontrolled studydescriptive researchdiastolic blood pressureDoppler echocardiographyechocardiographygrowth hormone deficiencyheart functionheart left ventricle enddiastolic diameterheart left ventricle endsystolic diameterheart performanceheart ventricle ejection timehormone substitutionhumanM mode echocardiographypediatric patientsystolic blood pressuretissue Doppler imagingtreatment durationadverse eventcardiovascular diseasecase control studyfemalefollow uphormone substitutionmalemetabolismpathologypituitary dwarfismprognosisprospective studyrisk factorArticle10.1016/j.ghir.2021.101432