Hizliateş C.G.Gülle S.Ergün Y.2024-07-222024-07-2220160022152Xhttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15996(Chemical Equation Presented) The novel heterocyclic compounds that have cycloalk[b]indole moiety bearing spiropiperidinone and spiropiperidinedione (3a, 3b, 3c, 5a, 5b, 8a, 8b, and 10a) were synthesized for the first time. The synthesis of spiropiperidinone and spiropiperidinedione structures was performed by a new method. These compounds are similar to sedative and hypnotic drugs such as methyprylon, glutethimide, and thalidomide. © 2015 HeteroCorporation.English4 methyl 1h spiro[cyclopenta[b]indole 2,3' piperidine] 1,2'(3h,4h)dione4 methyl 1h spiro[cyclopenta[b]indole 2,3' piperidine] 1,2',6' (3h,4h)trione4 methyl 1h spiro[cyclopenta[b]indole 2,3' piperidine] 2',3 (4h)dione4 methyl 1h spiro[cyclopenta[b]indole- 2,3' piperidine] 2',3,6' (4h)trione5 methyl 7,8 dihydro 5h spiro[cyclohepta[b]indole 9,3' piperidine] 2',6',10(6h)trione9 methyl 1,2 dihydrospiro[carbazole 3,3' piperidine] 2',4 (9h)dione9 methyl 1,2 dihydrospiro[carbazole 3,3' piperidine] 2',4,6' (9h)trione9,9' dimethyl 3, 4, 3', 4', di dihydrospiro[bicarbazole 2,3',2',3''dipiperidine] 1,2',6',1',2'',6''(9h,9'h)hexaonecycloalk[b]indole derivativeglutethimideheterocyclic compoundindole derivativemethyl 2 (2 cyanoethyl) 4 methyl 1 oxo 1,2,3,4 tetrahydrocyclopenta[b]indole 2 carboxylatemethyl 3 (2 cyanoethyl) 9 methyl 4 oxo 2,3,4,9 tetrahydro 1h carbazole 3 carboxylatemethyl 4 methyl 1 oxo 1,2,3,4 tetrahydrocyclopenta[b]indole 2 carboxylatemethyl 5 methyl 10 oxo 5,6,7,8,9,10 hexahydrocyclohepta[b]indole 9 carboxylatemethyl 5 methyl 6 oxo 5,6,7,8,9,10 hexahydrocyclohepta[b]indole 7 carboxylatemethyl 7 (2 cyanoethyl) 5 methyl 6 oxo 5,6,7,8,9,10 hexahydrocyclohepta[b]indole 7 carboxylatemethyl 9 (2 cyanoethyl) 5 methyl 10 oxo 5,6,7,8,9,10 hexahydrocyclohepta[b]indole 9 carboxylatemethyl 9 methyl 4 oxo 2,3,4,9 tetrahydro 1h carbazole 3 carboxylatemethyprylonpiperidine derivativespiropiperidine derivativespiropiperidinedione derivativethalidomideunclassified druganalytic methodArticlebiological activitychemical analysischemical reactiondrug structuredrug synthesispolymerizationstructure analysisArticle10.1002/jhet.2395