Dogru Y.Varol S.R.Nalcakan G.R.Akyuz M.Tas M.Ulman C.2024-07-222024-07-22202102504685http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13246Short Communications: Apelin, pentraxin3 (PTX3), and interleukin6 (IL6) parameters are known as inflammation markers and found to be related to endoplasmic reticulum (ER) stress. The aimof the studywas to investigate the effect of eccentric exercise-induced delayed onset muscle soreness (DOMS) on ER stress-related markers in young athletes. Objectives and Methods: ER stress and DOMS-related blood markers, maximal strength level, and rate of perceived exertion using the visual analog scale (VAS) were assessed before, immediately after, 24, 48, and 72 h after the muscle damage protocol. Results: IL6 peaked 24 h after while creatine kinase and lactate dehydrogenase enzyme levels reached their peaks at 72 h after the protocol. The level of apelin continued to increase throughout the four measurements, and PTX3 peaked at 24 h, and then declined to the levels before the protocol but the differences were not significant. The significant decrease in the strength and the significant increase in VAS continued 48 h after the protocol. Conclusion: ER is activated and ER stress occurred, due to increases in IL6, PTX3 and apelin levels after the test protocol concluded that a single vigorous eccentric exercise should be avoided in harmful effect on health as parallel with Physical Activity Guidelines Open Access. 2020 Yeliz Dogru et al. © 2021 De Gruyter. All rights reserved.EnglishAll Open Access; Gold Open Accessapelincreatine kinaseinterleukin 6pentraxin 3Articleblood analysisdelayed onset muscle sorenesseccentric exerciseeccentric muscle contractionendoplasmic reticulum stressendurance trainingfemoral condylefootball playerhumanhuman experimentknee functionmean platelet volumemetabolic regulationmuscle diseasemuscle exercisemuscle strengthphysical activityquadriceps femoris musclerange of motionvisual analog scaleArticle10.1515/TJB-2020-0014