Bor S.Kitapcioglu G.Kasap E.2024-07-222024-07-22201710079327http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15466AIM: To evaluate the prevalence of gastroesophageal reflux disease (GERD) with additional symptoms, relationship with Helicobacter pylori (H. pylori) of this country-wide study. METHODS: Data from 3214 adults were obtained with validated questionnaire. Eight hundred and forty-one subjects were randomized to be tested for H. pylori via the urea breath test. "Frequent symptoms" were defined heartburn and/or regurgitation occurring at least weekly. RESULTS: The prevalence of GERD was 22.8%, frequent and occasional heartburn were 9.3%-12.7%, regurgitation were 16.6%-18.7%, respectively. Body mass index (BMI) ≤ 18.5 showed a prevalence of 15%, BMI > 30 was 28.5%. The GERD prevalence was higher in women (26.2%) than men (18.9%) (P < 0001). Overall prevalence of H. pylori was 75.7%. The prevalence was 77.1% in subjects without symptoms vs 71.4% in subjects with GERD (χ2 = 2.6, P = 0.27). Underprivileged with the lowest income people exhibit a higher risk. CONCLUSION: GERD is common in Turkey which reflects both Western and Eastern lifestyles with high rate of H. pylori. The presence of H. pylori had no effect on either the prevalence or the symptom profile of GERD. Subjects showing classical symptoms occasionally exhibit more additional symptoms compared with those without classical symptoms. © 2017 Baishideng Publishing Group Inc. All rights reserved.EnglishAll Open Access; Green Open Access; Hybrid Gold Open AccessAdultBreath TestsFemaleGastroesophageal RefluxHeartburnHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedPrevalenceRandom AllocationSurveys and QuestionnairesTurkeyUreaalginic acidantacid agenthistamine H2 receptor antagonistnonsteroid antiinflammatory agentproton pump inhibitorureaadultArticleasthmabody masscoughingdyspepsiadysphagiaeructationfemalegastroesophageal refluxheartburnHelicobacter pylorihematemesishiccuphoarsenesshumanlowest income groupmalenauseanoncardiac chest painodynophagiapharyngitisprevalencesex ratioTurk (people)urea breath testvomitingbreath analysisgastroesophageal refluxheartburnHelicobacter InfectionsHelicobacter pyloriisolation and purificationmicrobiologymiddle agedquestionnairerandomizationTurkeyArticle10.3748/wjg.v23.i3.525