Aydemir Ö.Çubukçuoğlu Z.Erdin S.Taş C.Onur E.Berk M.2024-07-222024-07-22201415164446http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16718Objective: This study aimed to evaluate the relationship between oxidative stress markers and cognitive functions and domains of psychosocial functioning in bipolar disorder.; Methods: Oxidative stress markers, cognitive functions, and domains of psychosocial functioning were evaluated in 51 patients with bipolar disorder who were in remission. Correlation analyses between these parameters were calculated with data controlled for duration of illness and number of episodes.; Results: There was no statistically significant correlation between oxidative stress markers and cognitive functions. In terms of psychosocial functioning, significant correlations were found between malondialdehyde and sense of stigmatization (r = -0.502); household activities and superoxide dismutase (r = 0.501); participation in social activities and nitric oxide (r = 0.414); hobbies and leisure time activities and total glutathione (r = -0.567), superoxide dismutase (r = 0.667), and neurotrophin 4 (r = 0.450); and taking initiative and self-sufficiency and superoxide dismutase (r = 0.597). There was no correlation between other domains of psychosocial functioning and oxidative stress markers.; Conclusion: These results imply that oxidative stress markers do not appear to correlate clearly with cognitive impairment and reduced psychosocial functioning. However, there were some associations between selected oxidative markers and activity-oriented functional markers. This may represent a true negative association, or may be an artifact of oxidative stress being a state rather than a trait marker. © 2014 Associação Brasileira de Psiquiatria.EnglishAll Open Access; Gold Open Access; Green Open AccessActivities of Daily LivingAdultBiological MarkersBipolar DisorderCase-Control StudiesCognitionCognition DisordersCross-Sectional StudiesFemaleHumansMaleMiddle AgedNeuropsychological TestsOxidative StressPsychiatric Status Rating ScalesSocial AdjustmentTime Factorscyanocobalaminfolic acidglutathionehomocysteinemalonaldehydeneurotrophin 4nitric oxidepsychotropic agentsuperoxide dismutasebiological markeradultArticlebipolar disorderBipolar Disorder Functioning Questionnairecognitioncognitive defectcontinuous performance testcontrolled studycorrelation analysiscross-sectional studydisease durationenzyme linked immunosorbent assayfemaleHamilton scalehigh performance liquid chromatographyhouseholdhumanleisureLikert scalemajor clinical studymalemonotherapyneuropsychological testoxidative stresspsychologic testquestionnaireremissionrestRey Auditory Verbal Learning Testsense of stigmatizationSerial Digit Learning Testsocial behaviorsocial psychologyStroop testStructured Clinical Interview for DSM DisordersWisconsin Card Sorting TestYoung Mania Rating Scalebipolar disordercase control studycognitiondaily life activitymiddle agedoxidative stresspathophysiologyphysiologypsychological rating scalepsychologysocial adaptationtimeArticle10.1590/1516-4446-2013-1299