Synthesis of 5-fluorouracil dimer containing 2-amino-thiazole group via click reaction; [2-amino-tiyazol grubu içeren 5-florourasil dimerinin klik tepkimesi yoluyla sentezi]

Öztürkoğlu G.Ay E.Alp H.Ay K.2024-07-222024-07-22202121483736http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13764Since cancer is one of the leading diseases that cause human deaths in the world, the synthesis of anticancer or new compounds with fewer side effects is important. 5-Fluorouracil (5-FU) is one of the oldest compounds used for chemotherapy. In this study, 1,2,3-triazole bridge containing compound 4, which could have potential anticancer properties, was synthesized via the click reaction from the 5-FU and 2-aminothiazole using the molecular hybridization approach. The structural elucidation of the new compound was carried out using modern spectroscopic methods such as FTIR,1H,13C,19F, COSY, HSQC, HMBC and TOF-MS. © 2021, TUBITAK. All rights reserved.TurkishAll Open Access; Gold Open AccessSynthesis of 5-fluorouracil dimer containing 2-amino-thiazole group via click reaction; [2-amino-tiyazol grubu içeren 5-florourasil dimerinin klik tepkimesi yoluyla sentezi]Article10.31202/ecjse.789749