Parlak, YGumuser, GSayit, E2024-07-182024-07-180144-84201742-3406http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/4555The aim of this study was to determine the excretion of Samarium-153-ethylenediaminetetramethylphosphonic acid (Sm-153-EDTMP) in urine and to calculate the dose rate of its retention in the body as a function of time and the dose received by the skin of laboratory staff's finger. Urine samples were collected from 11 patients after intravenous injection of Sm-153-EDTMP. The measurements of dose rate were performed. Thermoluminescent dosemeters were used for absorbed dose measurements. Effective half-lives that were calculated from urine sample measurements were found as 7.1 +/- 3 h within the first 24 h. Whole body dose rates before collecting urine of patients were 60.0 +/- 15.7 mu Sv h(-1) for within 1 h following Sm-153-EDTMP administration. The highest finger radiation dose is to the right-hand thumb (3.8 +/- 2 mGy). The results of the study imply that patients who recieved Sm-153-EDTMP therapy should be kept a minumum of 8 h in an isolated room at hospital and that one staff should give therapy at most two patients per week.EnglishBONEPHARMACOKINETICSMETASTASESTOXICITYArticle