Özdemir İ.H.Özlek B.Çetin N.2024-07-222024-07-22202100220736http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13379Background: Data specifically addressed to whether atrial fibrillation (AF) would contribute to increasing the risk for severe forms of novel coronavirus disease (COVID-19) or worse prognosis remain unclear. Hence, we sought to assess the association of permanent AF with in-hospital outcomes in patients with COVID-19. Methods: This was a single-centered, retrospective, observational study including consecutive hospitalized patients with COVID-19. The primary outcome for the study was defined as all cause in-hospital mortality. Clinical characteristics and outcomes of patients with AF were compared to patients without AF. Results: Three hundred and fifty hospitalized COVID-19 patients (median age of 55 years, 55.4% men) were enrolled. Of them 40 (11.4%) had AF. Patients with AF were older; were more likely to have co-morbidities, abnormal chest radiography findings and deteriorated laboratory parameters such as D-dimer, troponin, albumin, urea. In-hospital mortality was higher in patients with AF compared to patients without AF (32.5% vs. 13.5%, log-rank p = 0.002, RR 2.40). The number of patients who needed intensive care unit (55% vs. 31%, p = 0.002) and invasive mechanical ventilation (35% vs 15.2%, p = 0.002) were also higher in the AF group. In addition, length of in-hospital stay was longer in patients with AF (median 8 vs. 7 days, p = 0.008). After adjustment for age and co-morbidities, multivariable analyses revealed that AF (HR: 2.426, 95% CI: 1.089–5.405, p = 0.032) was independently associated with in-hospital death. Conclusions: AF was seen with together markers of severe COVID-19, and the presence of AF was an independent predictor of in-hospital mortality in patients with COVID-19. © 2021 Elsevier Inc.EnglishAll Open Access; Green Open AccessAdultAgedAged, 80 and overAtrial FibrillationCOVID-19ElectrocardiographyFemaleHeart FailureHospital MortalityHumansMaleMiddle AgedRetrospective StudiesalbuminC reactive proteinD dimertroponin IureaadultArticlecause of deathcomorbiditycomputer assisted tomographycontrolled studycoronavirus disease 2019demographydisease associationelectrocardiographyfemalehospital mortalityhospitalizationhumanintensive care unitinvasive ventilationmajor clinical studymaleobservational studypermanent atrial fibrillationretrospective studythorax radiographyagedatrial fibrillationcomplicationheart failurehospital mortalitymiddle agedvery elderlyvirologyArticle10.1016/j.jelectrocard.2021.01.016