Kurt O.Özdal-Kurt F.Tuʇlu M.I.Akçora C.M.2024-07-222024-07-22201410520295http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16603We investigated the cytotoxic, neurotoxic, apoptotic and antiproliferative effects of extracts from Petalonia fascia, Jania longifurca and Halimeda tuna on the MCF-7 breast cancer cell line. J. longifurca extracts were more toxic than those of P. fascia and H. tuna. The algal extracts showed significant toxic effects at different dilutions. The toxic effects were due to increased oxidative stress and resulted in apoptosis. Algal toxicity may exert negative effects through the food chain or by direct interaction. Algal toxicity also has potential for cancer therapy. The toxic effects that we observed may be especially important for therapy for breast tumors. © 2014 The Biological Stain Commission.EnglishAntineoplastic AgentsApoptosisBreast NeoplasmsCell ProliferationCell SurvivalChlorophytaFemaleHumansLethal Dose 50MCF-7 CellsNeurotoxinsPhaeophytaPlant ExtractsRhodophytaSeawateralgaeHalimeda tunaJania longifurcaPetalonia fasciaantineoplastic agentneurotoxinplant extractsea waterapoptosisBreast Neoplasmsbrown algacell proliferationcell survivalchemistrydrug effectsfemalegreen algahumanLD50MCF 7 cell linemicrobiologypathologyred algaArticle10.3109/10520295.2014.917199