Tuncel E.T.Parvizi M.Kut E.Aydın M.Kasap E.2024-07-222024-07-22202313004948http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12155Background: We aimed to investigate the effect of hemoglobin/prognostic nutritional index and hemoglobin/red blood cell distribution, which are indicators of inflammation and nutrition, on prognosis and survival in patients with rectal cancer. Methods: The retrospective study reviewed medical records of 138 patients with rectal cancer who were followed up between 2010 and 2021. The effects of hemoglobin/red blood cell distribution, hemoglobin/prognostic nutritional index, tumor stage, and lymph node status on survival and prognosis were evaluated using univariate and multivariate analyses. Overall survival and disease-free survival were calculated for both groups. Results: Survival and prognosis were found to be significantly better in nonanemic patients with the hemoglobin/prognostic nutritional index higher than the cut-off value than in anemic patients with a normal or lower hemoglobin/prognostic nutritional index. Similarly, survival and prognosis were found to be significantly better in nonanemic patients with a hemoglobin/red blood cell distribution higher than the cut-off value than in anemic patients with a normal or lower hemoglobin/red blood cell distribution. Conclusion: The results indicated that nutrition and inflammatory markers have independent prognostic significance in rectal cancer. These markers are simple, inexpensive, and useful biomarkers commonly used in clinical practice, and they were found to predict overall survival and disease-free survival independently. Copyright © Author(s)EnglishAll Open Access; Gold Open AccessErythrocytesHemoglobinsHumansNeoplasm StagingNutrition AssessmentNutritional StatusPrognosisRectal NeoplasmsRetrospective Studiesalbuminbiological markerCA 19-9 antigencarcinoembryonic antigenhemoglobininflammatory markertumor markerunclassified drughemoglobinadultagedcancer prognosiscancer specific survivalcancer stagingcancer survivalclinical assessmentclinical practiceclinical significanceConference Paperdisease free survivalfemalehumanKolmogorov Smirnov testleukocyte countlymph vessel metastasislymphocytemajor clinical studymalemonocytemultivariate analysisneoadjuvant chemotherapynutritional statusoverall survivalperineural invasionplatelet countprognostic significanceprognostic nutritional indexrectum anterior resectionrectum cancerred blood cell distribution widthretrospective studyunivariate analysiserythrocytenutritional assessmentnutritional statusprognosisrectum tumorConference paper10.5152/TJG.2022.22203