Saruç M.Can M.Küçükmetin N.Tuzcuoglu I.Tarhan S.Göktan C.Yüceyar H.2024-07-222024-07-22200312341010http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20158Background: Intravenous somatostatin decreases acid secretion, splanchnic blood flow, and portal pressure, but the evidence for its efficacy in the treatment of non-variceal upper gastrointestinal bleeding has been mixed. We aimed to evaluate the vasoactive effect and possible mechanisms of somatostatin infusion in the cessation of non-variceal upper gastrointestinal bleeding. Material/Methods: Patients with non-variceal upper gastrointestinal bleeding without portal hypertension were enrolled in the study. They were given somatostatin infusion in a dose of 250 μgr/hour for 72 hours. Superior mesenteric arterial average flow velocity (SMA-V), SMA pulsatility index (SMA-PI), portal venous volume flow (PV-F), and renal artery resistance index (RA-RI) were measured two times for each patient by Doppler ultrasound; oncee on the first day of infusion therapy and again 6 hours or more after stopping the infusion. Results: 21 patients (12 male, mean age 44.1±9.9) with bleeding peptic ulcer were enrolled. During somatostatin infusion, PV-F was 33.7±19.7 cm3/sec. After stopping infusion, it increased to 56.3±16.0 cm3/sec (p=0.001). SMA-V was 39.7±13.1 cm/ sec and 64.4±15.1 cm/sec during somatostatin infusion and after cessation of somatostatin respectively (p=0.01). SMA-PI was 2.0±0.8 during somatostatin infusion but 2.8±0.8 without somatostatin infusion (p=0.02). However, RA-RI showed no difference between states with or without somatostatin infusion (p>0.05). Conclusions: Somatostatin infusion causes a decrease in arterial blood flow to the stomach and duodenum in patients with non-variceal upper gastrointestinal bleeding without portal hypertension. Somatostatin therapy also decreases portal blood flow while not altering renal blood.EnglishAdultDuodenumEsophageal and Gastric VaricesGastrointestinal HemorrhageHemodynamic ProcessesHormonesHumansMaleMiddle AgedPilot ProjectsRegional Blood FlowSomatostatinStatisticsStomachTreatment Outcomesomatostatinadultartery blood flowartery resistancearticleblood flow velocityclinical articlecontrolled studyDoppler echographydrug effectdrug efficacydrug infusionfemalehemodynamicshumanintestine blood flowkidney arterymalepeptic ulcer bleedingpilot studyportal vein blood flowpulse wavestomach blood flowsuperior mesenteric arteryupper gastrointestinal bleedingArticle