Ünak, TYildirim, YAvcibasi, UBiber, ZDuman, YÜnak, P2025-04-102025-04-100236-5731http://hdl.handle.net/20.500.14701/40218In this study, dithizone (diphenylthiocarbazone) has been separately radiolabeled with I-131 and with Tc-99m for preliminarily testing their radiopharmaceutical potentials on male albino rabbits. I-131-dithizone and Tc-99m-dithizone were intravenously injected to rabbits via their ear veins after anesthetizing with a mixture of Alfazyne and Alfamine (Serva) to determine their dynamic and static statuses in the metabolism. Also, Tc-99m as pertechnetate and I-131 as iodate were administered to rabbits as controls. Dynamic and static scintigrams were obtained using a gamma camera (Diacan Instruments). Dynamic scintigrams were obtained over the first half hour with frames of 1 minute following the administrations of the labeled compounds. Static images were obtained from posterior projection at different time intervals up to about 3 hours following the administration of the radiolabeled compounds. Tc-99m-dithizone was significantly uptaken by the pancreas in contrast to free Tc-99m. In the case of I-131-dithizone, the distribution of I-131 activity in the metabolism was clearly different than the case of free (131)stopI and the uptake of I-131-dithizone at the pancreas zone was also significant. These preliminary tests have clearly indicated that especially Tc-99m-dithizone has a significant potential to be used as a pancreatic radiopharmaceutical.EnglishArticle