Ay K.Ispartaloğlu B.Halay E.Ay E.Yaşa İ.Karayıldırım T.2024-07-222024-07-22201710542523http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/153444-Sulfanilamido substitued-1,2,3-triazoles conjugated with monosaccharides (8–17) including d-glucose, d-galactose, d-mannose, and d-fructose were synthesized in good yields from azidosugars with propargyl sulfanilamides using copper catalyst 1,3-dipolar cycloaddition reaction (CuAAC). The structures of new compounds were elucidated by liquid chromatography-mass spectrometry, infrared, one-dimensional- and two-dimensional-nuclear magnetic resonance techniques. All of the new compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeruginosa, and Candida albicans for their antibacterial and antifungal activities. Experimental results showed antimicrobial activity with minimum inhibitory concentrations values a ranging from 0.078 to 5.0 mg/mL against test microorganisms. © 2017, Springer Science+Business Media New York.English1,2,3 triazole derivative4 ({[4' acetamidobenzenesulfonyl]amino}methyl) 1 (2",3",4",6" di o acetyl beta dextro mannofuranosyl) 1h 1,2,3 triazole4 ({[4' acetamidobenzenesulfonyl]amino}methyl) 1 (2",3",4",6" di o isopropylidene beta dextro fructopyranosyl) 1h 1,2,3 triazole4 ({[4' acetamidobenzenesulfonyl]amino}methyl) 1 (2",3",4",6" tetra o acetyl beta dextro galactopyranosyl) 1h 1,2,3 triazole4 ({[4' acetamidobenzenesulfonyl]amino}methyl) 1 (2",3",4",6" tetra o acetyl beta dextro glucopyranosyl) 1h 1,2,3 triazole4 ({[4' acetamidobenzenesulfonyl]amino}methyl) 1 (6'' deoxy 1",2"3",4" di o isopropylidene alpha dextro galactopyranose 6" yl) 1h 1,2,3 triazoleantibiotic agentantifungal agentcarbohydrate derivativesulfanilamide derivativeunclassified drugantibacterial activityantifungal activityArticleBacillus subtilisCandida albicanscontrolled studydrug screeningdrug synthesisEnterococcus faecalisEscherichia coliin vitro studyKlebsiella pneumoniaeliquid chromatography-mass spectrometrymelting pointminimum inhibitory concentrationnonhumannuclear Overhauser effectproton nuclear magnetic resonancePseudomonas aeruginosaSalmonella enterica serovar TyphimuriumStaphylococcus aureusArticle10.1007/s00044-017-1864-3