Altinisik, MKahraman, NSKurt, EMayali, HKayikcioglu, O2025-04-102025-04-100165-5701http://hdl.handle.net/20.500.14701/38597Purpose To investigate the quantitative differences in optical coherence tomography angiography (OCTA) data between type 2 diabetes patients without clinically detectable diabetic retinopathy (DR) and healthy subjects. Methods Thirty-nine patients with type 2 diabetes without DR and 41 age- and sex-matched healthy controls were recruited. The vessel density and foveal avascular zone (FAZ) area in the superficial capillary plexus and deep capillary plexus were measured using Nidek RS-3000 Advance (R) and compared between patient cohorts. Foveal vessel density (%) and FAZ (%) were also calculated. Results A significant decrease in vessel density has been observed in the deep capillary plexus of the patients compared to healthy individuals (5.58 +/- 0.98 mm(2) versus 6.15 +/- 0.89 mm(2), p < 0.001). However, there were no significant differences in other parameters between cohorts (p > 0.05 in all parameters). Despite the decrease of deep capillary plexus density in the macular region, there was no significant change observed in foveal vessel density (p:0.44). It has also been observed that the duration of diabetes mellitus correlates with vessel density decrease in deep capillary plexus (R:-0.52; p < 0.001). In both groups, all parameters in deep capillary plexus were significantly higher than superficial capillary plexus (p < 0.001 for all parameters). Conclusions OCTA can identify quantitative changes in DCP before the manifestation of clinically apparent retinopathy. DCP-VD reduction may be an earlier finding than FAZ enlargement. Despite the reduction of VD, FVD could be preserved for a certain period of time in DM patients.EnglishArticle1573-2630