Kuscu N.K.Yildirim Y.Koyuncu F.Var A.Uyanik B.S.2024-07-222024-07-22200309320067http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20111Introduction: Hyperemesis gravidarum (HG) is associated with higher levels of serum β-hCG levels and hyperthyroidism. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is reported to enhance secretion of β-hCG from trophoblastic cell line. Methods: We measured serum levels of IL-6, thyroid hormones and β-hCG of hyperemetic patients and gestational age-matched controls to search for a difference between the two groups. Results: There was a significant difference in β-hCG (p=0.028), though IL-6 levels were higher in the hyperemetic group, it did not reach a significant level. Interleukin-6 positively correlated with β-hCG (r=0.38 and p=0.13).EnglishAdultChorionic GonadotropinFemaleHumansHyperemesis GravidarumInterleukin-6PregnancyPregnancy Trimester, FirstStatistics, NonparametricThyrotropinThyroxineTriiodothyroninechorionic gonadotropin beta subunitinterleukin 6thyroid hormoneadultarticleclinical articlecontrolled studycorrelation analysisdisease associationfemalegestational agehormone releasehumanhyperemesis gravidarumhyperthyroidismtrophoblastArticle10.1007/s00404-002-0412-6