Avcıbaşı U.Türkyarar T.Karadağ A.Bakan B.Yavaşoğlu N.Ü.K.Kuşat K.Akgöl S.Gülcemal D.Tekin V.Müftüler F.Z.B.Topal G.Parlak Y.Gümüşer F.G.2024-07-222024-07-22202102365731http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13204The aim of this study is the synthesis of a novel 99mTc-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with 99mTc. The radiochemical yield of approximately the 99mTc-labeled compound amounted to 97 ± 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate. © 2021, Akadémiai Kiadó, Budapest, Hungary.Englishpolymertechnetium 99manimal tissueArticlechemical structurecontrolled studycytotoxicityembryoHEK293 cell linehemolysis assayhumanhuman cellin vitro studyin vivo studyincubation timelipophilicitymalenonhumanpancreasprostateradiolabelingratsynthesisthyroid glandWistar ratArticle10.1007/s10967-021-07817-6