Çolak H.Kilicarslan B.Tekce H.Tanrisev M.Tugmen C.Aktas G.Kursat S.2024-07-222024-07-22201517449979http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16469Cardiovascular (CV) diseases are still the most important cause of morbidity and mortality in both patients receiving hemodialysis (HD) treatment and individuals with renal transplantation (Rtx). Measurement of epicardial adipose tissue (EAT) thickness is an easily applied, cheap, and useful recent method predicting increased CV risk. We aimed to compare EAT changes in HD and Rtx patients and the association between EAT and inflammatory and CV volume markers in both groups. A total of 124 patients: 45 Rtx, 43 HD patients and 36 healthy controls were enrolled in the study. Laboratory parameters and inflammatory markers (interleukin-6 [IL-6] and high sensitive C-reactive protein [Hs-CRP]) were evaluated from venous blood samples after an overnight fast. EAT thickness was measured with transthoracic echocardiography. The levels of Hs-CRP, IL-6, systolic and diastolic blood pressures, left atrial (LA) diameter, left atrial index (LAI), left ventricular mass (LVM) and LVM index (LVMI) were significantly higher in the HD patients than in the other groups. EAT was positively correlated with age, body mass index (BMI), time on dialysis, serum creatinine, total cholesterol, Low density lipoprotein-cholesterol, and LVM in Rtx group and positively correlated with age, BMI, duration of dialysis, Hs-CRP, IL-6, LAI and LVMI and inversely correlated with inferior vena cava collapse index (IVC-CI) in HD group. EAT thickness of RTx patients (whose previous HD duration was similar to those in HD group) are similar to the healthy population and significantly thinner than patients on HD. Therapeutic Apheresis and Dialysis. © 2015 International Society for Apheresis.EnglishAdipose TissueAdultAnalysis of VarianceAnthropometryBiological MarkersBody Mass IndexC-Reactive ProteinCardiovascular DiseasesCase-Control StudiesEchocardiography, DopplerFemaleHumansInflammationInterleukin-6Kidney Failure, ChronicKidney TransplantationMaleMiddle AgedPericardiumPrognosisRenal DialysisRisk AssessmentSurvival RateTreatment OutcomealbuminC reactive proteincalciumcholesterolcreatinineglucosehemoglobinhigh density lipoprotein cholesterolinterleukin 6low density lipoprotein cholesterolparathyroid hormonephosphatetriacylglycerolbiological markerC reactive proteininterleukin 6adipose tissueadultagealbumin blood levelArticleblood analysisblood pressure measurementbody massbody surfacecalcium blood levelcardiovascular parameterscardiovascular riskcholesterol blood levelcontrolled studycreatinine blood leveldiastolic blood pressurediet restrictionechocardiographyepicardial adipose tissueepicardiumfemaleglucose blood levelgraft recipientheart left atriumheart left atrium indexheart left ventricle ejection fractionheart left ventricle masshemodialysishemodialysis patienthemoglobin blood levelhumaninflammationkidney transplantationlaboratory testmajor clinical studymaleparathyroid hormone blood levelphosphate blood levelpriority journalsystolic blood pressurethicknesstransthoracic echocardiographytreatment durationtriacylglycerol blood levelvenous bloodadipose tissueadverse effectsanalysis of varianceanthropometrybloodCardiovascular Diseasescase control studycomparative studyDoppler echocardiographyechographyinflammationKidney Failure, Chronickidney transplantationmetabolismmiddle agedmortalitypathophysiologypericardiumproceduresprognosisrenal replacement therapyrisk assessmentsurvival ratetreatment outcomeArticle10.1111/1744-9987.12276