Agarwal P.Deni̇z S.Jain S.Alderremy A.A.Aly S.2024-07-222024-07-22202003784371http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14018In this work, we propose a new optimal perturbation iteration method for solving the generalized Fitzhugh–Nagumo equation with time-dependent coefficients. This research reveals that the new proposed technique, with the aid of symbolic computations, provides a straightforward and impressive mathematical tool for solving nonlinear partial differential equations. Implementing this method to Fitzhugh–Nagumo equation illustrates its potency. Convergence analysis also shows that OPIM, unlike many other methods in literature, converges fast to exact analytical solutions of the nonlinear problems at lower order of approximations. © 2019EnglishChromosomesGenetic algorithmsIterative methodsPartial differential equationsPerturbation techniquesExact analytical solutionsIteration methodNagumo equationNonlinear partial differential equationsPopulation geneticsSemi-analytical techniquesSymbolic computationTime-dependent coefficientsNonlinear equationsArticle10.1016/j.physa.2019.122769