Börekci E.Kara A.Kılıç M.Tanık N.Ozan Z.T.Yıldırım T.Aral Y.2024-07-222024-07-22202115901874http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13350Purpose: To investigate the relationship between the intensity of neuropathic pain and the severity of osteopenia in type 2 diabetic patients with painful diabetic peripheral neuropathy (painful DPN). Methods: In 220 patients with type 2 diabetes included in the screening, the presence of neuropathic pain was evaluated using the Douleur Neuropathique 4 Questions (DN4) scoring system. One hundred forty-five patients with painful DPN were identified and included in the study. Socio-demographic and laboratory evaluations were made and bone mineral density (BMD) of these patients was evaluated by the dual-energy x-ray absorptiometry (DEXA) method. Results: There was a significant correlation between the neuropathic pain score and the total T scores of the lumbar spine and femur in patients with painful DPN. According to the regression analysis (standard coefficients), the DN4 score (0.498); the level of vitamin D (− 0.246) and the female sex (0.236) for the lumbar spine region; age (0.387); DN4 score (0.261); and vitamin D level (− 0.155) for the femur region were independently influencing factors on the development of osteoporosis. When osteoporosis (T score ≤ − 2.5) of the lumbar spine was analyzed by binary logistic regression, the risk of osteoporosis in women was 4.4 times higher, and the risk increased with increasing DN4 score. Conclusion: The increase of neuropathic symptoms in patients with DPN is an effective and important factor in the development of diabetic osteopenia. © 2020, Fondazione Società Italiana di Neurologia.EnglishAbsorptiometry, PhotonBone DensityBone Diseases, MetabolicDiabetes Mellitus, Type 2Diabetic NeuropathiesFemaleHumansalbuminanalgesic agentbisphosphonic acid derivativecalciumvitamin DadultArticlebone densitycross-sectional studydiabetic neuropathydiabetic patientdouleur neuropathique 4 questionsdual energy X ray absorptiometryfemalefemurhumanhuman tissuelumbar spinemajor clinical studymalemiddle agedneuropathic painnon insulin dependent diabetes mellitusosteopeniaosteoporosisreceiver operating characteristicscoring systemcomplicationdiabetic neuropathydiagnostic imagingmetabolic bone diseasenon insulin dependent diabetes mellitusphoton absorptiometryArticle10.1007/s10072-020-04915-3