Şener A.Tozlu I.Genç H.Bildirici I.Arisoy K.2024-07-222024-07-2220070022152Xhttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19317(Chemical Equation Presented) 1,5-Diphenyl-1H-pyrazole-3,4-dicarboxylic acid-4-ethyl ester 2, obtained from the 4-ethoxycarbonyl-5-phenyl-2,3-furandione 1 and N-benzylidene-N1-phenyl hydrazine, was converted via reactions of its acid chloride 3 with various alcohols or N-nucleophiles into the corresponding ester 5 or amide derivatives 6, respectively. In addition, 2 was decarboxylated to give ethyl 1,5-diphenylpyrazole-4-carboxylate 4. Nitrile 7 derivative of 2 was also obtained by dehydration of 6a in a mixture of SOCl 2 and DMF. While cyclocondensation reaction of 2 with hydrazine hydrate leads to the formation of pyrazolo[3,4-d]pyridazine-4,7-dione 8, the reaction of 3 with anhydrous hydrazine provided a new bis pyrazole derivative 9.English1,5 diphenyl 1h pyrazole 3,4 dicarboxylic acid 4 ethyl ester4 (ethoxycarbonyl) 1,5 diphenyl 1h pyrazole 3 carboxylic acid4 ethoxycarbonyl 5 phenyl 2,3 furandionealcohol derivativeamidecarboxylic acid derivativeester derivativeethyl 1,5 diphenylpyrazole 4 carboxylatehydrazinen benzylidene n' phenylhydrazinen,n dimethylformamidenitrilephenylhydrazine derivativepyrazole derivativepyrazolo[3,4 d]pyridazine 4,7 dionepyrrole derivativeunclassified drugarticlechemical reactionchemical structurepolymerizationreaction analysissynthesisArticle10.1002/jhet.5570440516