Aksun S.Gökcimen A.Kahyaoglu F.Demirci B.2024-07-222024-07-22201902504685http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14727Objective: Statins and Paracetamol have widespread use in clinic and both drugs possess similar side effects; therefore, we investigated if drug-interaction occurs when the combination of these two drugs is used during therapy. Materials and methods: A total of 32 (12-15 months old) grown-up male rats were divided into four groups: Control group, RSV group (10 mg/kg Rosuvastatin/daily), APAP group (50 mg/kg Paracetamol/5 days/weekly), RSV + APAP (10 mg/kg Rosuvastatin/daily + 50 mg/kg Paracetamol/5 days/weekly). At the end of 8 weeks of chronic treatment, the blood and tissue samples were taken under the Ketamine and Xylasine anesthesia (50 mg/kg and 5 mg/kg, respectively). Results: In the liver, sinusoidal dilatations, pyknotic nuclei and hemorrhagic foci are more frequently seen in the group receiving combination therapy; although serum liver functions among groups were not significantly different. Kidney histopathologic alterations in APAP and RSV + APAP groups were found more distinct than in RSV alone group. Inducible nitric oxide synthase activity was highly increased with combination therapy in liver and kidney tissues. Conclusion: RSV-Paracetamol interaction may occur as an important drug interaction histopathologically even before it is manifested biochemically in the clinic. © 2019 De Gruyter. All rights reserved.EnglishAll Open Access; Gold Open Accessalbumininducible nitric oxide synthasenitric oxideparacetamolrosuvastatinureaadultanimal experimentanimal tissueArticlecell structurecolorimetrycontrolled studydrug exposureenzyme activityenzyme linked immunosorbent assayhistopathologyimmunohistochemistrykidney functionkidney hemorrhageliver functionliver necrosismalenonhumanrattissue degenerationArticle10.1515/tjb-2018-0252